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Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

机译：通过分子修补的蛋白质进化：来自配体依赖性祖先的核受体超家族的多样化。

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摘要

Phylogenetic reconstruction of the structure and function of the ancestor of the nuclear receptor protein family reveals how functional diversity evolves by subtle tinkering with an ancestral template.

机译：系统发育重建核受体蛋白家族祖先的结构和功能揭示了如何通过祖先模板的微妙修补来发展功能多样性。

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Bridgham, Jamie T.; Eick, Geeta N.; Larroux, Claire; Deshpande, Kirti; Harms, Michael J.; Gauthier, Marie E. A.; Ortlund, Eric A.; Degnan, Bernard M.; Thornton, Joseph W.;
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年度 2010
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正文语种 {"code":"en","name":"English","id":9}
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1. Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor [J] . Jamie T. Bridgham, Geeta N. Eick, Claire Larroux, PLoS Biology . 2010,第10期

机译：通过分子修补的蛋白质进化：来自配体依赖性祖先的核受体超家族的多样化。
2. Origin and evolution of transmembrane Chl-binding proteins: hydrophobic cluster analysis suggests a common one-helix ancestor for prokaryotic (Pcb) and eukaryotic (LHC) antenna protein superfamilies [J] . Garczarek L., Poupon A., Partensky F. FEMS Microbiology Letters . 2003,第1期

机译：跨膜Chl结合蛋白的起源和进化：疏水性聚类分析表明原核（Pcb）和真核（LHC）天线蛋白超家族是常见的单螺旋祖先
3. Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator- activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription [J] . Juan Llopis, Stefan Westint, Mercedes Ricotet Proceedings of the National Academy of Sciences of the United States of America . 2000,第8期

机译：共激活因子类固醇受体共激活因子1和过氧化物酶体增殖物激活的受体结合蛋白与核激素受体的配体依赖性相互作用可以在活细胞中成像，并且是转录所必需的
4. HDX Reveals DNA Binding Modulates Ligand-dependent Co-activator Interaction with the VDR/RXR Nuclear Receptor Complex [C] . Jun Zhang, Michael J. Chalmers, Keith R. Stayrook, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：HDX显示DNA结合调节与VDR / RXR核受体复合物的配体依赖性共激活物相互作用
5. Modulation of peroxisome proliferator-activated receptor alpha-mediated gene transcription of rat peroxisomal acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase by members of the nuclear hormone receptor superfamily. [D] . Kassam, Altaf. 2001

机译：核激素受体超家族成员对过氧化物酶体增殖物激活的受体α介导的大鼠过氧化物酶体酰基辅酶A氧化酶和烯酰辅酶A水合酶/ 3-羟酰基辅酶A脱氢酶的基因转录的调节。
6. Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor [O] . Jamie T. Bridgham, Geeta N. Eick, Claire Larroux, 2010

机译：通过分子修补的蛋白质进化：来自配体依赖性祖先的核受体超家族的多样化。
7. Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor [O] . Bridgham, J T, Eick, G N, Larroux, C, 2010

机译：通过分子修补进行蛋白质进化：来自配体依赖性祖先的核受体超家族的多样化

Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

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